Escudo de la República de Colombia

English

Nose cells could repair backbone lesions

Transplanting rat olfactory ensheathing cells (OECs) to the bone marrow is now an alternative to restore mobility to people with brainstem lesions; 30 rats recovered their mobility after this unique experiment.

Bogotá D. C., 07 de diciembre de 2016Agencia de Noticias UN-

Any progress in this field is hope for close to 894,000 Colombian nationals which have brainstem lesions and cannot move their lower limbs.

Olfactory ensheathing glia are present from the simplest invertebrates to human beings.

Olfactory ensheathing glia are an alternative to restore mobility to people with bone marrow lesions.

These types of cells have the capability to replace lost neurons.

Olfactory ensheathing glia cells are present from the simplest invertebrates to human beings. Glia is Greek for "glue", referring to the property of maintaining neurons together. 

“The olfactory system and OECs (as an exceptional case in the nervous system), can replace lost nervous cells as they wrap neuronal axons and produce the conditions that make olfactory neurons multiply. This has made these cells to be transplant candidates for the central nervous system,” said Universidad Nacional de Colombia (UNal) Faculty of Veterinary Medicine and Zootechnics Professor and Biomedical Sciences Ph.D. candidate Lucía Botero Espinosa. 

Rosa Gómez and Kemel Ghotme, researchers from the Universidad de La Sabana and UNal colleague Orlando Chaparro also contributed to the project thanks to funding from the Colombian Administrative Department of Science Technology and Innovation. Botero demonstrated that rats with complete brainstem lesion recovered the mobility of their lower limbs after an OEC transplant, carried out in an autologous manner (cells obtained from the same individual.) 

She says that these types of cells have been used in Colombia during an acute lesion stage, i.e. minutes after an accident, although they had not been tested in chronic stages, in other words, months after a traumatic event. 

For the aforementioned reason, the purpose of the project was to demonstrate that these cells obtained from the nose can repair lesions not only at the primary level but also in later stages. Any progress in this field is hope for close to 894,000 Colombian nationals which have brainstem lesions and cannot move their lower limbs. 

“There are palliative procedures to treat medullar lesions which help mitigate pain, but none of them contribute to recover the functionality of affected patients,” said Botero.  

Reestablished connection 

During the first stage of the project, the researchers grew and maintained a 10-day culture of pathogen–free rat OECs. They used 28 rats, 18 of which were transplanted and 10 used as control. 

After the procedure, the researchers analyzed the evolution of the rats after 75 days and control every other day. They carried out three tests: First the rats were placed in a corridor to observe mobility, second on top a sloped grid and third they were lifted to see if they could sustain themselves on the hind legs. 

"Before the transplant, the rats practically crawled, and the mobility of their hind legs was null. After the operation a good portion of the rats recovered their mobility,” said Botero. 

She stated that where there is a brainstem lesion axon connections are completely lost, a situation known as glial scar formation and the cavity is entirely hollow with no neuronal link, therefore no mobility. 

“The transplanted OECs regenerated medullary axons and reestablished the connection,” she added. 

The following stage consisted of assessing axon regeneration and remyelination of rat bone marrow. Myelin is the substance which makes neuronal impulses travel faster across axons. 

With a technique known as confocal laser scanning microscopy which helps visualize green colored axons and red glial scarring, they proved that after three months of the transplant axons had regenerated and the glial scarring had been reduced. They also observed that axons effectively remyelinated. 

Thanks to the results of the research project Botero was granted first prize in the “Oral presentation” category during the Veterinary Congress held in León (México). 

In fact, Botero announced that the following step to test OECs transplants in other species, especially in dogs. "Many dog owners aware of this new alternative ask us to use the option on their pets so they can restore their mobility. If we demonstrate the success of the technique in dogs, Colombian science is closer to offering the alternative to people with these types of lesions,” she added.

(Por: end/
)
N.° 25

Otras noticias

Jesús Guevara, director del cortometraje documental <i>La Perla</i>.

Artes & Culturas

abril 24 de 2017

Tumaco y fútbol, pasión documental

Un joven realizador tumaqueño explora la relación de su ciudad natal con el...

La presidenta de Chile recibió a los rectores y delegados de las principales universidades de América Latina.

Educación

abril 24 de 2017

Responsabilidad política y universidades públicas, temas de la Asamblea de la Red de Macrouniversidades

La presidenta de la República de Chile, Michelle Bachelet, junto con la...

Diecisiete personas perdieron la vida en esta tragedia.

Medioambiente

abril 24 de 2017

Erosión hídrica requiere más investigación en Manizales

La disminución de la capa vegetal en Manizales, es decir, la falta de árboles...

El riesgo de enfermedad cardiaca aumenta con la enfermedad renal crónica.

Salud

abril 24 de 2017

Enfermedad renal crónica también afecta al corazón

La enfermedad renal crónica es padecida por unas 40.000 personas en todo el...

Educación

abril 24 de 2017

Escuela de Minas de Medellín: 130 años de “Trabajo y Rectitud”

A la celebración por el cumpleaños de la sesquicentenaria Universidad Nacional...

En Colombia se estima que el 2,3 % del total de casos de cáncer registrados corresponde al oral.

Ciencia & Tecnología

abril 24 de 2017

Con proteína de calostro de las vacas diseñan péptido que ataca cáncer oral

En la primera leche que produce la vaca después de parir un ternero podría...

Un total de 26.238 aspirantes presentaron la prueba en la Sede Bogotá.

Educación

abril 23 de 2017

Multitudinaria cita con el conocimiento en la U.N.

Este no es un domingo cualquiera. Antes de las siete de la mañana, la entrada...

Educación

abril 23 de 2017

43.250 estudiantes presentaron examen de admisión a la U.N.

Con toda normalidad se llevó a cabo este domingo la jornada académica en 27...

La marcha por la ciencia partió a las 11 a.m. desde la plaza central de la U.N.

Ciencia & Tecnología

abril 22 de 2017

FOTOGALERIA: Las universidades marcharon por la ciencia

La Universidad Nacional de Colombia (U.N.) Sede Bogotá fue el punto de...

Identifican bacterias asociadas con contaminantes atmosféricos.

Ciencia & Tecnología

abril 21 de 2017

Identifican bacterias relacionadas con contaminantes atmosféricos y más en UN Periódico

Este domingo 23 de abril, la edición 209 del periódico de la Universidad...