Escudo de la República de Colombia

English

Nose cells could repair backbone lesions

Transplanting rat olfactory ensheathing cells (OECs) to the bone marrow is now an alternative to restore mobility to people with brainstem lesions; 30 rats recovered their mobility after this unique experiment.

Bogotá D. C., 07 de diciembre de 2016Agencia de Noticias UN-

Any progress in this field is hope for close to 894,000 Colombian nationals which have brainstem lesions and cannot move their lower limbs.

Olfactory ensheathing glia are present from the simplest invertebrates to human beings.

Olfactory ensheathing glia are an alternative to restore mobility to people with bone marrow lesions.

These types of cells have the capability to replace lost neurons.

Olfactory ensheathing glia cells are present from the simplest invertebrates to human beings. Glia is Greek for "glue", referring to the property of maintaining neurons together. 

“The olfactory system and OECs (as an exceptional case in the nervous system), can replace lost nervous cells as they wrap neuronal axons and produce the conditions that make olfactory neurons multiply. This has made these cells to be transplant candidates for the central nervous system,” said Universidad Nacional de Colombia (UNal) Faculty of Veterinary Medicine and Zootechnics Professor and Biomedical Sciences Ph.D. candidate Lucía Botero Espinosa. 

Rosa Gómez and Kemel Ghotme, researchers from the Universidad de La Sabana and UNal colleague Orlando Chaparro also contributed to the project thanks to funding from the Colombian Administrative Department of Science Technology and Innovation. Botero demonstrated that rats with complete brainstem lesion recovered the mobility of their lower limbs after an OEC transplant, carried out in an autologous manner (cells obtained from the same individual.) 

She says that these types of cells have been used in Colombia during an acute lesion stage, i.e. minutes after an accident, although they had not been tested in chronic stages, in other words, months after a traumatic event. 

For the aforementioned reason, the purpose of the project was to demonstrate that these cells obtained from the nose can repair lesions not only at the primary level but also in later stages. Any progress in this field is hope for close to 894,000 Colombian nationals which have brainstem lesions and cannot move their lower limbs. 

“There are palliative procedures to treat medullar lesions which help mitigate pain, but none of them contribute to recover the functionality of affected patients,” said Botero.  

Reestablished connection 

During the first stage of the project, the researchers grew and maintained a 10-day culture of pathogen–free rat OECs. They used 28 rats, 18 of which were transplanted and 10 used as control. 

After the procedure, the researchers analyzed the evolution of the rats after 75 days and control every other day. They carried out three tests: First the rats were placed in a corridor to observe mobility, second on top a sloped grid and third they were lifted to see if they could sustain themselves on the hind legs. 

"Before the transplant, the rats practically crawled, and the mobility of their hind legs was null. After the operation a good portion of the rats recovered their mobility,” said Botero. 

She stated that where there is a brainstem lesion axon connections are completely lost, a situation known as glial scar formation and the cavity is entirely hollow with no neuronal link, therefore no mobility. 

“The transplanted OECs regenerated medullary axons and reestablished the connection,” she added. 

The following stage consisted of assessing axon regeneration and remyelination of rat bone marrow. Myelin is the substance which makes neuronal impulses travel faster across axons. 

With a technique known as confocal laser scanning microscopy which helps visualize green colored axons and red glial scarring, they proved that after three months of the transplant axons had regenerated and the glial scarring had been reduced. They also observed that axons effectively remyelinated. 

Thanks to the results of the research project Botero was granted first prize in the “Oral presentation” category during the Veterinary Congress held in León (México). 

In fact, Botero announced that the following step to test OECs transplants in other species, especially in dogs. "Many dog owners aware of this new alternative ask us to use the option on their pets so they can restore their mobility. If we demonstrate the success of the technique in dogs, Colombian science is closer to offering the alternative to people with these types of lesions,” she added.

(Por: end/
)
N.° 25

Otras noticias

La motivación de los estudiantes fue uno de los aspectos destacados por los pares evaluadores. (Fotos: Nicolás Bojacá / Agencia de Noticias UN)

Educación

octubre 20 de 2017

Maestría en Ingeniería-Geotecnia sobresale por su capital humano

La motivación de los estudiantes, la formación de los docentes y las...

Salón de Octubre 2017 es una plataforma de muestra de trabajos y proyectos de estudiantes y egresados de arquitectura de tres sedes de la U.N. (Fotos: Unimedios.)

Artes & Culturas

octubre 20 de 2017

“El urbanismo está sujeto a la naturaleza, no al revés”

El arquitecto mexicano Mario Schjetnan plantea que actualmente los desarrollos...

Fuerzas Militares apoyan la Jurisdicción Especial para la Paz.

Política & Sociedad

octubre 20 de 2017

Las fuerzas militares no son un obstáculo para la paz

“Somos constructores de paz dentro de un escenario nuevo, confuso y complejo....

Tradicionalmente la langosta espinosa se pesca en el Caribe.

Medioambiente

octubre 20 de 2017

Langosta y caracol en medio del litigio limítrofe del Caribe

Además de estar amenazados por la sobreexplotación, la pesca de estos...

Para evaluar los puertos marítimos del mundo se aplicaron ocho criterios.

Economía & Organizaciones

octubre 20 de 2017

Cartagena se raja en evaluación de puertos marítimos

Por ubicación geográfica y condiciones socioeconómicas, el puerto mejor...

Productos realizados por los menores después de la capacitación.

Educación

octubre 20 de 2017

Niños de sectores vulnerables, líderes emprendedores

Servilleteros, separadores de libros, piezas gráficas y cajas de regalos, todos...

Ciencia & Tecnología

octubre 20 de 2017

La U.N. participa en Open Innovation Summit Colombia

Profesores y estudiantes presentaron proyectos de innovación con el fin de...

Ciencia & Tecnología

octubre 20 de 2017

FIA Innova: ciencia, emprendimiento e innovación

25 trabajos entre ponencias y pósteres forman parte de la cuarta versión de FIA...

Con innovación en biotecnología se puede contribuir al fortalecimiento de la industria.

Economía & Organizaciones

octubre 20 de 2017

Bioeconomía, esencial para el crecimiento de Colombia

La gran biodiversidad del país podría estimular los avances en biotecnología,...

El tesoro Quimbaya es una de las colecciones de arte precolombino más valiosas del país.

Política & Sociedad

octubre 19 de 2017

El tesoro Quimbaya debe ser devuelto en defensa del patrimonio cultural

“Las piezas deben ser devueltas en defensa de los derechos humanos de los...